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    Your Position: Home > Services > Protein Expression Services > Beacon Single B Cell Screening Technology
    Beacon Single B Cell Screening Technology

    The Beacon single-cell optofluidic system introduced by Clongene facilitates the development of antibody drugs, tumor immunity and other cell biology research. It can introduce tens of thousands of single cells into nano upgraded micro-chamber for single cell isolation, detection, culture and export of integrated operation. Clongene can obtain positive monoclonal antibodies within 35 days by using Beacon single-cell optofluidic system, which greatly improves the efficiency of antibody screening, thus speeding up the process of antibody drug discovery.

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    Service Advantages
  • High throughput: up to 4 chips can be run simultaneously, screening about 50,000 cells
  • Short cycle: the monoclonal antibody screening was shortened from 1-2 months to 1 day
  • Automated screening process: import, culture, cloning, assay, screening, export of integrated operation
  • High probability of capture of target clones: retain the diversity of B cells and obtain high quality positive clones at the early stage of discovery
  • Natural paired antibodies: obtain high quality natural paired antibodies directly
  • McAb Development Service Content based on Beacon Platform

    Service Step

    Service Description



    Animal immunization

    - 3-5 Balb/C mice were immunized

    - Detection of serum titer in mice

    15 days

    - Five ELISA positive clones, each clone had 2 tubes of frozen cells

    - 1 mg purified antibody

    - COA

    Plasma cell extraction and Beacon sorting

    - Plasma cells from mouse spleen were extracted

    - Use Beacon for separation plasma cells

    - Extract mRNA, reverse transcription, amplification heavy/light chain sequences

    5 days
    Recombinant antibody expression and verification

    - Recombinant expression antibody

    - Antibody purification

    - Antibody to verify

    2 weeks

    Beacon Single B Cell Screening Service Process
  • Animal immunization
  • Spleen/Bone marrow single cell suspension
  • Beacon sorting
  • mRNA extraction
  • Amplification cDNA
  • Vector construction
  • Antibody expression
  • Antibody performance identification
  • Contact
    Contact Us
  • Phone: +86-571-88617879
  • Email: cro_service@clongene.com